Mathematical modelling has emerged as a critical tool for long-term wastewater management, particularly for simulating complicated biological processes. This study focuses on modelling and simulating of Al-muamirah wastewater treatment plant whose system is an oxidation ditch using GPS-X simulator to investigate the plant performance among four scenarios in different conditions. Samples were measured weekly over eight weeks, which were taken from the treatment plant's influent and effluent wastewater. The contamination parameters tested for these samples were the biochemical oxygen demand (BOD), the chemical oxygen demand (COD), and the total suspended solids (TSS). COD and TSS coefficients were chosen in the model because calibration values close to their true values were reached, while the true value of the BOD was not reached, so it was not taken as a calibration parameter. The results showed that the values of COD and TSS in the effluent wastewater were; 47 mg/L and 9 mg/L for the first scenario, 57 mg/L and 73 mg/L for the second scenario, 66 mg/L and 14.97 mg/L for the third scenario, 74 mg/L and 42 mg/L for the fourth scenario, respectively. The concentrations of pollutants
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