IMAGING FEATURES IN THE EVALUATION OF PATIENTS WITH BRAIN AND MANDIBULAR METASTASES IN BREAST CANCER WOMEN FROM THE NORTH-EASTERN REGION OF ROMANIA

This study aimed to explore the imaging features, immunohistochemical profiles, and molecular characteristics of brain and mandibular metastases stemming from breast cancer (BC). Introduction: Brain metastases (BM) represent a common and devastating manifestation of BC. BM are particularly prevalent in BC phenotypes expressing human epidermal growth factor receptor 2 (HER2-positive) marker and triple-negative subtypes and often occur following metastatic spread to various sites. BM represent a major contributor to morbidity and mortality in individuals with metastatic BC. Material and Methods: A retrospective analysis was conducted on 47 patients diagnosed with both brain metastases and facial masses as sites of metastases. The results predominantly indicated invasive ductal carcinoma, with a slightly higher incidence in cases affecting the right breast. In most cases, the intervention performed was a modified Madden mastectomy. Discussions: Our study highlights the greater aggressiveness of BC in younger women and the marked heterogeneity in tumor response to oncological treatment. Conclusions: Facial mass involvement resulting from metastases from BC cases is rare, but signifies