Backgroud: Merkel cell carcinoma is a cutaneous tumor, also known as neuroendocrine carcinoma, that is infrequent and highly aggressive, with a high mortality rate. 1 It primarily affects individuals over 60 years of age, those with immunosuppression, or those infected with the polyomavirus (MCPyV). It is an underdiagnosed tumor due to the nonspecificity of its clinical and dermatological manifestations. The definitive diagnosis is made by histopathological study, with identification of the sentinel lymph node being essential, since the presence of metastases is associated with a significant decrease in five-year survival. Although there is no optimal treatment, surgery remains a therapeutic pillar, complemented by radiotherapy and immunotherapy as adjuvant treatments. Material And Methods: The study was conducted using a mixed-method design, comprising a descriptive literature review conducted in scientific databases (PubMed, SciELO, Cochrane Library, and Elsevier), prioritizing recent population-based studies addressing the incidence, mortality, and survival associated with Merkel cell carcinoma. This was complemented by clinical follow-up of a 55-year-old female patient diagnose
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