Effectiveness of platelet-rich fibrin and chitosan as adjuvants for the treatment of chronic periodontitis

This article reviews the effectiveness of platelet-rich fibrin (PRF) and chitosan as adjunctive treatments in chronic periodontitis, an inflammatory disease affecting tooth-supporting tissues. Chitosan, a natural biopolymer, has demonstrated antimicrobial and regenerative properties, while PRF facilitates healing by reducing inflammation and deepening tissue attachment. Through a systematic review of recent studies, different parameters such as gingival index, periodontal pocket depth and plaque accumulation were evaluated. The results indicated that both biomaterials significantly improve periodontal treatment outcomes, suggesting their potential as effective adjuvants in periodontal therapy. However, further studies with larger samples are recommended to validate these findings in the long term