Pemphigus vulgaris is a chronic inflammatory autoimmune, intraepithelial blistering potentially life threatening disease. It initially manifests in the form of intraoral lesions, which may spread to mucous membrane and skin. It is characterized by the production of autoantibodies against intercellular substances. Eighty to ninety percent of patients with pemphigus vulgaris develop oral lesions and in 60% of cases oral lesions are the first sign therefore a dentist must be familiar with clinical manifestations of pemphigus vulgaris for early diagnosis and treatment.
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