The present paper shows how the development of synthetic nanostructured biomaterials, such as multisubstituted hydroxyapatite (msHAP) with Mg2+, Zn2+ and Sr2+ ions is important and beneficial at the same time for the normal functioning of the body. Moreover, the paper discusses a broad topic of major importance in orthopedic and dental surgery, namely the incorporation of msHAP into the polymeric matrix of poly lactic acid (PLA). This composite is used in order to cover the surface of the titanium implant in order to obtain bone integration and heal bone fractures. The review also highlights the importance of improving silver nanoparticle (SNPs) coating in order to combat postoperative infections. Through such approaches, medicine has managed to evolve considerably, and the contributions brought by great personalities and young researchers in the field have increased its area of applicability.
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