Myocardial perfusion imaging (MPI) is an important non-invasive imaging method, which allows the assessment of perfusion in the cells of the myocardial wall. The images are obtained after administration of a radiopharmaceutical at rest and/or after maximal stress (physical effort or pharmaceutical stress). Infarction areas or scars will not show any uptake of the radiopharmaceutical, neither in rest nor at stress (fixed defects), while the ischemic area will show reduced uptake at stress with recovery to normal perfusion at rest (reversible defects). MPI is a complex technique and it requires an experienced team to foresee, avoid, correct or minimize the artifacts that might appear in all the phases of the study In this paper, we will present the most important categories of artifacts, based on the category of problem where they were generated. We will also present some solutions for limiting these artifacts or for recognizing and minimizing their effect for those which cannot be avoided.
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