Background: Chronic kidney disease (CKD) is a progressive condition characterized by impaired kidney function or structural damage that persists for more than three months. This study aimed to assess the effectiveness of a structured teaching programme on knowledge and practice regarding self-care management among chronic renal failure (CRF) patients undergoing hemodialysis at PES General Hospital, Kuppam. Andhra Pradesh. Methods: A quantitative, pre-experimental one-group pre-test post-test design was used. A total of 40 CRF patients were selected using a convenience sampling technique. Data were collected through a structured questionnaire and checklist. Results: Demographically, 57.5% of participants were aged between 46–65 years, 85% were male, and 75% lived in rural areas. In the pre-test,57.5%hadmoderateknowledge,and70%demonstrated adequate practice. Following the intervention, 90% had adequate knowledge and 97.5% had adequate practice. The mean knowledge score improved from 17.03 (SD=5.916) in the pre-test to 24.55 (SD=4.018) in the post-test. Statistical analysis showed a significant improvement in both knowledge and practice scores post-intervention. Conclusion: The fin
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