Innovative Discovery Studies of Anti Lungs Cancer Active Drug Substances in Medicinal Chemistry

The discovery study of anti cancer active drug substance of (2S,2′S)-2,2′-[[2,2′- Diamino-4,4′,6-trioxo-1,4,4′,6,7,7′-hexahydro-1′H,5H-5,6′-bipyrrolo[2,3-d]pyrimidine-5,5′- diyl]bis(ethylenebenzene-4,1-diylcarbonylimino)] dipentanedioic acid was synthesized and characterized by medicinal chemistry bath way, also this product was obtained via the associated with the synthesis of pemetrexed disodium was performed. The possibility of (2S,2′S)-2,2′-[[2,2′-Diamino-4,4′,6-trioxo-1,4,4′,6,7,7′- hexahydro-1′H,5H-5,6′-bipyrrolo[2,3-d]pyrimidine-5,5′-diyl]bis(ethylenebenzene-4,1-diylcarbonylimino)] dipentanedioic acid forming has been mentioned in literature, but no study on this structure has been published yet. This paper describes the development of the synthesis methods and preclinical studies for this compound and discusses their structure elucidation on the basis of NMR experiments and MS data. The identification of anti cancer drug activity of this compound by preclinical test, it should be useful for identify the new anticancer drug in pemetrexed generation.