Diabetes mellitus is a silent killer that claims about 2 million lives annually. Endoplasmic-reticulum (ER) stress has been linked to type-2 diabetes. This study evaluated the effect of Bambusa vulgaris leaf ethanolic extract (B.V.E.E.) on ER-stress induced by Streptozotocin (STZ) in rats. Rats were divided into six groups and induced with the diabetes using streptozotocin (65 mg/kg) except the control group. Bambusa vulgaris (100, 200 and 400 mg/kg) were administered to the induced rats for twenty-one (21) days. The rats were sacrificed and blood collected for haematology while the liver was harvested for biochemical analysis. The expression of [(activating transcription factor 4 (ATF4), activating transcription factor 6 (ATF6), protein kinase RNA-like endoplasmic reticulum kinase (PERK), tribbles 3 (TRB3), transcription factor C/EBP homologous protein (CHOP), IRE1, interleukin 6 (IL-6), interleukin 1? (IL-1?) and tumor necrosis factor alpha (TNF-?)] genes was done using reverse transcriptase polymerase chain reaction (RT-PCR). Result showed that B.V.E.E. reduced fasting blood glucose in diabetic rats and lowered the activity of AST, ALT and ALP when compared to diabetic un-treate
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