Could the association of sunitinib and stereotactic ablative radiotherapy lead to abscopal effect in metastatic renal cell carcinoma?

Simultaneous prescription of systemic targeted therapy and Stereotactic Ablative Radiotherapy (SABR) is being used increasingly in various histological types of oligometastatic/oligoprogressive tumors. The underlying mechanisms of the synergistic effect are not yet well known. This case report concerns the interaction between a tyrosine kinase inhibitor and SABR in a patient affected by oligoprogressive metastatic renal cell carcinoma.