Thymic small cell carcinoma is an exceedingly rare diagnosis with undefined treatment options and, typically, poor prognosis. A 69-year-old female presented to the Emergency Department with chest pain and was found on Computed Tomography (CT) to have a multilobulated cystic mass in the anterior mediastinum. Magnetic Resonance Imaging (MRI) demonstrated a 7 x 8 x 8 cm mediastinal mass suspicious for thymoma. Biopsies of enlarged lymph nodes in levels 4L and 7 were negative for malignancy. The patient was taken for surgical resection of the mediastinal mass. After standard sternotomy, the mass was noted to be contiguous with the thymus. The specimen was removed en bloc and surgical pathology revealed high grade neuroendocrine carcinoma, measuring 9.0 cm in greatest dimension, consistent with small cell carcinoma of the thymus. Fibrous adhesions to the lung were noted but all margins and lymph nodes were negative for malignancy. Brain MRI was unremarkable and multidisciplinary tumor board decided to proceed with adjuvant chemotherapy. Patient is currently doing well without symptoms of recurrence one year post-operatively.
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