Introduction: The discoloration of the denture base resins is one of the shortcomings of this type of dental materials, and it could be determined through various visual and instrumental methods. The aim of the current study was to evaluate the color stability of 3Dprinted and conventional denture base resins after immersion in different staining solutions. Materials and methods: A total of 200specimens were manufactured from two types of materials: 3D printed dental resin NextDent Denture 3D+ (NextDent, 3D Systems, The Netherlands) and heat-polymerized PMMA Vertex (3D Systems, The Netherlands), which were immersed in four types of colorants - artificial saliva, coffee, red wine and coke (n = 25). For measuring the color changes (CIE-L*a*b* system) of all specimens after storage in artificial saliva for 24 h at 37 degrees C (T0), a spectrophotometer SpectroShade Micro (SpectroShade, USA) was used. After seven days (T1), 14 days (T2) and 21 days (T3), the mean ∆E values were calculated and compared by Bonferonni post-hoc test. The data were processed using thestatistical software SPSS 26. The level of significance forrejecting the null hypothesis was fixed at p<0,05. Results: Th
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