Among the group of multifactorial pathologies that are increasingly common and with high social importance in human populations are hypertension and migraine. Currently, about 27% of the world's adult population suffers from hypertension and about 11.4% – from migraine. Purpose: The aim of the present study is to investigate hypertension and migraine frequency among representatives of the reproductive population in Bulgaria and to characterize the potential relationships between these diseases and the factors of sex, age and AB0 blood groups. Material and methods: A total of 817 individuals aged between 18 and 59 years are included in the study. They voluntarily have filled out a questionnaire, giving disease information (hypertension and migraine) after they have been diagnosed by a physician. AB0-blood group affiliation has been determined in laboratory conditions by a routine technique. The statistical analysis has been performed using the IBM SPSS Statistics software package, version 22.0 Results: Differences in the frequency of hypertension and migraine have been found depending on sex, age and blood group of the individuals. It has been established that in the majority of the
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