EVALUATION OF THE ANTIGENIC ACTIVITY OF ATTENUATED VIRUS STRAINS USED IN THE DESIGN OF ANIMAL VACCINES

The article presents materials on studies of the antigenic activity of virus strains – components of associated vaccines – on laboratory and target animals. It was found that attenuated strains of infectious rhinotracheitis viruses (IRT-VBF-VGAVM No. 404), diarrhea (VD-VBF-VGAVM No. 406), parainfluenza-3 (PG-VBF-VGAVM No. 403), respiratory syncytial virus (RSV-VBF-VGAVM No. 405), rotavirus (RTV-VBF-VGAVM No. 401) and coronavirus (KV-VBF-VGAVM No. 407) are not reactogenic, and have shown a high antigenic activity, causing an active development of antiviral antibodies in both laboratory (mice) and agricultural (cattle) animals in sufficiently high titers, and they can be successfully used for the design of mono-and associated antiviral vaccines for the prevention of pneumoenteritis in calves.