EVENT-FREE SURVIVAL OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION DURING 36 MONTHS AFTER PPCI IN COMBINATION WITH COMBINED PROTOCOL OF DISTANT ISCHEMIC CONDITIONING AS A METHOD OF CARDIO PROTECTION

Background. Reperfusion injury occurs after revascularization of the coronary artery in patients with myocardial infarction (MI) significantly contributing to the development of chronic heart failure. This article describes the results of studying the effectiveness of one of the promising cardioprotection strategies aimed at limiting reperfusion injury. Materials and methods. Patients with acute anterior MI with ST elevation (STEMI) (n = 87) were included in an open-label prospective randomized controlled trial. Intervention group (IG) patients underwent primary percutaneous coronary intervention (PPCI) and remote ischemic preconditioning in combination with delayed postconditioning (RIPerPostC) (n = 43). Control group patients (CG) underwent only standard PPCI (n = 44). Event-free survival was estimated by Kaplan-Meier curves. Results. A comparative analysis of the frequency of the composite endpoint (re-hospitalizations for the underlying disease, repeated MI and death from cardiac causes) by the 36th month of follow-up had shown that the proportion of patients who reached the endpoint was significantly higher in the CG: 45.5% vs 20.9% in the IG (p = 0.015). According to the resu