Objectives: Hand hygiene among healthcare workers is crucial as their hands can transmit microbes between patients and the environment, leading to hospital-acquired infections (HAIs). HAIs are significant challenges in healthcare facilities, with rates of 5% in Europe and 5.7% to 19.1% in low- and middle-income countries. Vietnam faces similar issues, with HAI rates ranging from 3.5% to 10% of hospital admissions. Nu-merous studies have shown that adherence to hand hygiene practices is essential to re-ducing HAIs. This study aims to i) Describe the current adherence to regular hand hy-giene compliance and 2) Describe the factors influencing adherence of regular hand hy-giene compliance among health staff in hospitals worldwide. Methods: We conducted a narrative review on hand hygiene compliance. The review included original studies in English, published within the last 10 years, assessing hand hygiene compliance using an assessment tool, and analyzing related factors. Results: Out of 988 retrieved publications, 899 articles were excluded due to duplica-tion or insufficient criteria. After abstract screening, 80 full-text studies were reviewed. Findings indicated generally low ha
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