Zero-day cyber threats continue to be a significant challenge for securing digital infrastructure in future economies. As such, there is a need for defensive systems that are intelligent and adaptive and, most importantly, trustworthy. However, traditional intrusion detection systems (IDSs) are typically static and lack the capability to reason, adapt, and explain their decisions. To address these limitations, this paper proposes an agentic artificial intelligence (AI)-driven framework for zero-day cyber threat detection based on adaptive reasoning. The framework improves zero-day awareness through autonomous reasoning, adaptive decision-making processes, and interpretable behavioral analysis. The key contribution of this research is the integration of three components, namely epistemic uncertainty estimation, embedding-based structural deviation assessment, and adaptive thresholding. These components allow the framework to make self-regulated decisions beyond fixed-model inference. The effectiveness of the framework was assessed using two benchmark datasets, Network Security Laboratory – Knowledge Discovery and Data Mining (NSL-KDD) and Telemetry and Network Traffic for Internet o
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