Objectives. The aim of the study was to compare the postoperative and oncologic outcomes of small bowel versus gastric surgery for gastrointestinal stromal tumors (GISTs). Background. The feasibility of the small bowel resection for GIST has been demonstrated; however, its impact on outcomes, particularly its oncologic safety for tumors greater than 5 cm, remains unknown. Methods. Among 93 patients treated for a stromal tumor in SUUB between 2001 and 2015, patients who underwent primary resection for a gGIST smaller than 20 cm (N = 66), by either small bowel (group S, n = 28) or gastric surgery (group G, n = 38), were compared. Multivariable analyses and propensity score matching were used to compensate for differences in baseline characteristics. Results. In hospital mortality and morbidity rates in groups S and G were 0.0% versus 2.6% (P = 0.086) and 10.7% vs 18.4% (P = 0.004), respectively. Small bowel resection was independently protective against in hospital morbidity (odds ratio 0.54, P = 0.014). The rate of R0 resection was 96.4% in group S and 92.1% in group G (P = 0.103). After 1:1 propensity score matching (n= 22), the groups were comparable according to age, sex, tumor l
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