Objective. Gout is an autoinflammatory disorder driven by monosodium urate crystal–induced activation of interleukin-1 (IL-1) signaling. Despite the central role of IL-1 in the inflammatory cascade, data on IL-1 gene polymorphisms in Turkish patients with gout are scarce. We aimed to evaluate variants within the IL-1 gene cluster and to assess their potential associations with inflammatory markers. Methods. Seventy gout patients and 106 age- and sex-matched healthy controls were included. Genomic deoxyribonucleic acid (DNA) extracted from peripheral blood was genotyped for five IL-1 single-nucleotide polymorphisms (rs16944, rs1143634, rs1800587, rs2234650, rs315952) using real-time polymerase chain reaction (PCR) with melting-curve analysis. Genotype and allele frequencies were compared between groups, and laboratory variables were assessed across genotypes within the patient cohort. Statistical significance was set at p < 0.05. Results. The rs16944 AG genotype was significantly more common in gout patients than in controls. No significant case–control differences were found in allele frequencies or in the distributions of the remaining polymorphisms. Within the gout cohort, sev
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