SEVERE HYPONATREMIA, HYPERTENSION, ACUTE DETERIORATION OF RENAL FUNCTION IN A YOUNG FEMALE WITH LUPUS NEPHRITIS

Lupus nephritis is one of the most important organ involvement in patients diagnosed with Systemic Lupus Erythematosus (SLE). It requires aggressive and prolonged immunosuppression in order to induce and maintain remission. There is always a risk of adverse events. It is presented the case of a young woman diagnosed with SLE and active lupus nephritis with acute renal failure, who developed persistent hyponatremia after immunosuppression with Cyclophosphamide was started. The case emphases both the need for synthetic immunosuppression as well as the adverse events that may occur during treatment. Close monitoring of the clinical and biological parameters during immunosuppressive therapy is essential as even one minimally modified parameter may prove important in the evolution of the case. Measures to prevent one side effect do not prevent the developing of other.