Hypothesis of neuroinflammation in depression

Numerous clinical and experimental studies show that neuroinflammation hypothesis became a foundation pillar in the etiopahtogenesis of depression alongside the monoamine hypothesis, given the fact that the existence of a pro-inflammatory status was repeatedly proven both is human subjects and laboratory animals. Depression induced by cytokine treatment in cancer and by interferon treatment in viral chronic hepatitis became a frequent therapeutic entity in the later years, on the opposite pole being important proofs of amelioration in psychic and neurovegetative depressive symptoms with anti-cytokine and anti-inflammatory treatment.