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Clinico-pathological correlations in malignant brain tumors

, Diana Stanca, Cornelia Zaharia, , Valerica Tudorica, · Romanian Journal of Neurology · 2012

Objective. The aim of our study was to evaluate the cognitive impairment in patients diagnosed with malignant brain tumors. Material and methods. We enrolled in our study 105 patients diagnosed with astrocytomas, hospitalized in the Clinic of Neurology between January 2006 and December 2010. Depending on the histology of the tumor, the study-group was composed of 19 cases diagnosed with diffuse astrocytomas, 13 cases with anaplastic astrocytomas and 73 cases with glioblastomas. Each patient was evaluated by neurological and neuro-imagistic exam (computed tomography and/or nuclear magnetic resonance). Each patient was evaluated in the term of disability using Karnofsky Performance Status, which is a scale commonly used in patients with cancer to quantify functional status. Presurgical cognitive functions of the patients were assessed using Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), The results were analyzed using Student’s T test and Chi-Squared test, considering statistically significant p<0.05. Results. In the terms of mean age, the statistical analysis didn’t show a significant difference between the three groups of patients. Also, we observ

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