A biosensor is an analytical instrument that combines a biological component with a physicochemical detector to detect a chemical molecule. A biosensor is a biological detection device that combines a biological component with a transducer to perform biochemical amount measurement. Biosensors are often designed to convert physical, chemical, or biological events into measurable signals, providing qualitative and/or quantitative data on the target analytes. While the topic of biosensors has attracted a lot of attention from scientists, combining it with micro fluidics could result in even more substantial gains in terms of sensitivity and specificity, resolution, automation, throughput, repeatability, dependability, and accuracy. Biosensors-on-chip (BoC) might thus serve as a bridge between diagnostics in central laboratories and diagnostics at the patient's bedside, allowing for significant breakthroughs in point-of-care (PoC) diagnostic applications. The purpose of this publication is to present an up-to-date review of BoC system development and their most current application in cancer, infectious diseases, and neurological disorders diagnosis. Leland C. Clark invented enzyme elec
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