There are presented the main principles and possibilities of simultaneous chemoradiotherapy, including intra-tumoral administration of antitumor drugs in combination with irradiation of primary bone tumors with soft tissue components, metastatic damage of bones, soft tissue tumors as well as superficial tumors and metastases. On the example of 23 patients the high efficiency of synchronous combined therapy is showed. The possibility of using low total doses of ionizing radiation in order to significantly increase the local cytotoxicity of antitumor drugs directly in the tumor focus is substantiated. The proposed variant of synchronous combined therapy makes it possible to obtain a pronounced local effect with minimal systemic toxicity.
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