Oxidative stress in a neuron is induced by several physiological and pathological processes. Within the pathophysiological processes, ischemia-reperfusion injury has major role in the neurons and brain, because the neurons and brain are very sensitive to oxidative stress as compared to other tissues due to their high oxygen consumption rate and rich poly unsaturated fatty acid content but low antioxidant levels. Results of rodent studies indicated that exposure to volatile anesthetics as a result of ischemia-reperfusion injury can active leukocytes or alveolar macrophages, which, in turn, release inflammatory mediators and reactive oxygen species (ROS). This release of inflammatory mediators, ischemia/reperfusion injury, and ROS has been clearly demonstrated in generalized inflammatory reactions involving the production of phagocytic cells such as leucocytes and microglia. A common volatile general anesthetic is desflurane and results of several recent papers indicated that it  an increase oxidative stres
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