For decades, efforts to standardize medical care have struggled to fundamentally reduce errors and unjustified variations in medical practice, largely due to the influence of the human factor. The formalization of clinical guidelines and computer-assisted interpretation makes it possible to provide decision-support tools to improve health-care quality. They can better influence clinician behavior than narrative guidelines. Medical ontologies and algorithms based on such ontologies allow the interpretation of formalized clinical documents (guidelines). To support health professionals as consultants, systems must provide reliable knowledge and rely on approaches explicitly explaining their recommendations. Integrating software engineering, knowledge engineering, and artificial intelligence advancements can provide health-care professionals with computer-interpretable clinical guidelines. These should be decision-support complexes combined under a common terminological framework capable of understanding patient health documents. The research focuses on an emerging concept of manufacturing systems working with digital clinical guidelines. The paper presents an architectural principle,
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