Breast cancer is one of the most prevalent cancers affecting women globally. Early diagnosis is crucial for effective treatment and improved survival rates. Imaging techniques such as mammography and ultrasound are widely used conventional diagnostic methods. However, these methods have limitations, including low sensitivity and specificity, especially in patients with dense breast tissue. For instance, mammograms miss approximately 20% of breast cancer cases, leading to false negatives and delayed treatment that can have fatal consequences. To address these challenges, artificial intelligence (AI)-based diagnostic tools have been developed to assist healthcare professionals in accurately detecting breast cancer. These tools work in conjunction with human radiologists to improve diagnostic outcomes. In addition, biomarkers present a promising non-invasive, more convenient alternative for the early detection of breast cancer, potentially overcoming the limitations of traditional screening methods. Various biomarkers, such as circulating tumor cells, cell-free tumor nucleic acids, and microRNAs, have shown promise in early breast cancer diagnosis. A systematic literature review is ne
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