Intracardiac masses can be presented in multiple forms. Differentiating the type of the mass is often challenging but crucial to direct the management. This report describes a 31-year-old female who presented with multiple intracardiac masses after one hour of tranexamic acid administration. Multiple imaging modalities used in our patient to reach the final diagnosis of intracardiac thrombosis and to follow up the response to treatment. Tranexamic acid has been used commonly in trauma patients to reduce the risk of death with a good safety profile. Large prospective trials have failed to show a significant association of vascular occlusive events with TXA administration. This case demonstrates the need for close monitoring in post‐trauma TXA recipients to avoid thrombotic complications. Heparin was used successfully to treat these thrombi, and the patient was discharged on enoxaparin to finish six months course of treatment.
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