The enteric microbiota influences gene expression in the colonic epithelium. H. pylori (Helicobacter pylori) affects gastric growth factors, cytokines, and tumor cell markers, potentially benefiting the host. The interaction between H. pylori and human microbiota is complex but appears beneficial in gastric disease development. This publication discusses the human microbiota, gastric microbiome, chronic H. pylori colonization, and the bacterium’s role in gastric disease. The interplay between the gastric bacterium and human microbiota during infection is also explored. The human gut has the most abundant and complex microbial community and performs vital roles in food digestion and nutrient uptake, extraction of absorbable vitamins, and inhibition of pathogen colonization. Helicobacter pylori is a highly specialized human gastric pathogen, predominantly colonizing the gastric mucus layer, on or adherent to the underlying gastric epithelial cell surfaces. Many studies have suggested that the gastric microbiome is related to H. pylori infection, and some bacterial species can be used for the detection or diagnosis of H. pylori infection. Human microbiome and genome analysis has revol
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