Machine Learning and Knowledge Extraction have evolved from algorithmic tools for pattern recognition into a unifying foundational scientific framework underpinning virtually all of today’s groundbreaking advances, enabling systematic discovery, interpretation and understanding across domains. This paper introduces a comprehensive research agenda that defines currently the future of innovation in Artificial Intelligence. We identify ten interrelated research frontiers that collectively map the transition from data-driven learning to knowledge-centric, trustworthy, and sustainable intelligence. These frontiers span the full spectrum of future AI research: from physics-informed and hybrid architectures that embed causality and domain knowledge, to multimodal and embedded intelligence that ground AI in real-world contexts; from interpretable and responsible design principles that ensure transparency and fairness, to safe and sustainable deployment in open-world environments. Together, these directions delineate a coherent roadmap toward AI systems that not only predict but also explain, reason, and collaborate. Future AI can be seen as a new member of your research lab, an active part
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