Objective Effective health communication is a cornerstone of public health promotion. This study aimed to develop and evaluate a pedagogical model to equip future physicians with essential skills in audience-tailored science communication, thereby contributing to the public health workforce. Methods The study involved 79 undergraduate students enrolled in the elective science communication course. The newly proposed A-SPIRE model (Anchoring, Searching, Processing, Integrating, Realizing, Evaluating) was applied in a teaching unit on “Precision Science Communication.” A pre-post design was used, with data collected via questionnaires, knowledge tests, and analysis of student-created communication works. Results Students’ understanding of precision science communication concepts and recognition of its importance significantly improved post-course ( P < 0.05). The overall distribution of knowledge test scores shifted u
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