Big data technology plays an important role in the prevention and control of public health emergencies such as the COVID-19 pandemic. Current studies on model construction, such as SIR infectious disease model, 4R crisis management model, etc., have put forward decision-making suggestions from different perspectives, which also provide a reference basis for the research in this paper. This paper conducts an exploratory study on the construction of a big data prevention and control model for public health emergencies by using the grounded theory, a qualitative research method, with literature, policies, and regulations as research samples, and makes a grounded analysis through three-level coding and saturation test. Main results are as follows: (1) The three elements of data layer, subject layer, and application layer play a prominent role in the digital prevention and control practice of epidemic in China and constitute the basic framework of the “DSA” model. (2) The “DSA” model integrates cross-industry, cross-region, and cross-domain epidemic data into one system framework, effectively solving the disadvantages of fragmentation caused by “information island”. (3) The “DSA” model
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