Structural diversification of N-acylhydrazones by click chemistry

We describe the synthesis of a novel N-acylhydrazone via Copper(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC) as key step for constructing triazole-functionalized systems. The synthetic approach involved preparation of a protected-phenol azide through a copper(I)-induced coupling of an aryl bromide with sodium azide, followed by aldehyde functionalization to yield the key precursor for N-acylhydrazone formation. The optical properties of the target N-acylhydrazone were investigated, revealing blue fluorescence both in solid-state and aqueous solutions.