A Review on Different Manifestations of Crouzon Syndrome

Introduction: Crouzon syndrome (CS), the most common craniosynostosis condition, which could lead to several developmental complications. This study aimed to review the different manifestations of CS. Material and Methods: In order to find the relevant articles, the databases of PubMed, Scopus, Web of Science, and Cochrane Library were searched using the term “Craniofacial Dysostosis” and its relevant entry terms. All English-language articles regarding the CS were included in the study. After removing the duplicate articles, two authors independently screened the title and abstracts of the included articles. Disagreements were resolved through voting and discussion with the third author. Then full-text of articles were screened and the articles were categorized depending on regarding their main topic. Results: The search yielded 449 results in different databases. After removing the duplicates, 331 results remained. Then, 182 were excluded as not completely relevant by screening the abstracts. The remaining 149 studies were assessed for the eligibility criteria. Of them, 74 were excluded due to the following reasons: (1) unavailable full text; (2) discussing other types of cranios