The objective of the current study is to ascertain the clinical audit of nursing care about the administration of tissue plasminogen activator (t-PA) drugs in patients diagnosed with cerebral thromboembolic stroke. In this quasi-experimental study, a total of 16 triaged cases of patients with acute cerebral embolic stroke, referred to both the emergency and neurology departments, were examined. These cases were divided into two groups: intervention and control. The method of event sampling and a three-part checklist for t-PA drug injection were employed through a six-stage clinical audit process. In the current investigation, the mean age of the participants in the control group was 57.63 (SD=3.58), while in the intervention group, it was 55.51 (SD=3.58). The adherence to nursing care protocols before the administration of the t-PA drug witnessed a significant enhancement following the execution of the clinical audit cycle (P=0.045). Similarly, the compliance rate of nursing care during the injection of the t-PA drug also saw a significant rise after the implementation of the clinical audit cycle (P=0.02). The nursing performance metrics improved after the clinical audit cycle’s im
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