Background: Polycystic kidney disease (PKD) in Persian cats is a common genetic disorder that accounts for 10% of chronic renal failures. Objectives: This study aimed to assess the effect of PKD progression on renal resistive index (RI), plasma renin activity (PRA), angiotensin II (ANG II), aldosterone levels, and systolic blood pressure in Persian cats. Methods: Fifty Persian cats (25 with PKD and 25 healthy) were included in the present study. First, the blood pressure of each cat was measured, and then their PRA, ANG II, and aldosterone enzymes were evaluated using an ELISA test. Additionally, B-Mode ultrasonography was performed in the PKD group to evaluate and calculate cysts’ diameter and overall volume (OVC). Furthermore, the RI was computed by pulsed-wave Doppler in all cats. Results: There were no significant differences in the systolic blood pressure between healthy and PKD cats (138.84±2.89 vs 140.92±2.35 mm Hg). PRA, aldosterone, and ANG II were significantly higher in the PKD group compared to the healthy group (3.64±0.36 vs 2.26±0.029 ng/mL, P<0.01; 80.45±2.35 vs 30.98±1.75 pg/mL, P<0.0001; and 53.54±3.22 vs 30.08±3.06 pg/mL, P<0.0001, respectively). Statist
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