Background & Aims Psychiatric nurses are responsible for establishing or maintaining a safe and therapeutic environment for patients and ensuring optimal clinical supervision of restraints based on the standards in the psychiatric ward. This study aimed to determine the knowledge, attitude, and practice of nurses working in the Razi Psychiatric Hospital, Tabriz, Iran, regarding the use of physical restraints. Materials & Methods This is a descriptive cross-sectional study conducted in 2022. The study population consists of all nurses working in the psychiatric wards of Razi Hospital in Tabriz, Iran. We selected 200 eligible nurses using a convenience sampling method. The data collection tools were a demographic form and a knowledge, attitude and practice scale regarding the use of physical restraints. The data were statistically analyzed in SPSS software version 18. Results The mean scores of knowledge, attitude and practice were 19.36±1.73 (out of 23), 36.51±4.60 (out of 60) and 65.19±3.29 (out of 75), respectively. The practice score had a statistically significant correlation with work experience in psychiatric wards (P=0.048) and knowledge score (P=0.016). Conclusion It
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