Introduction: The global landscape of medical education has been profoundly transformed by the COVID-19 pandemic. E-learning plays a significant role in promoting students’ self-directed learning. However, end-of-course surveys have indicated that students do not perceive e-learning to be as beneficial as anticipated. The current study explores e-learning utilization and the challenges impeding its effectiveness, highlighting the difficulties encountered by students during their initial experiences. Methods: A qualitative study was conducted in the academic year–2022-2023 at the Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City (UMP). Sixteen students from years 3 to 5 participated in the interviews. Results: The findings revealed three themes: (1) the inadequacy of e-learning functions to support learning activities, (2) barriers preventing students from increasing e-learning usage for learning activities, and (3) recommendations for maximizing the utilization of e-learning platforms. Discussion and conclusions: To fully harness the e-learning potential, it is crucial to address the challenges faced by students and continuously improve the platform based
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