Background: during natural aging, cellular and molecular changes in the colonic mucosa contribute to chronic damage and the development of various neoplasia, including colorectal cancer (CRC). Aim: to assess the age peculiarities of mRNA expression in samples of normal mucosa from various parts of the colon. Patients and Methods: the study included 95 patients. Normal colonic mucosa biopsies were derived during videocolonoscopy from different parts of the colon, i.e., the right colon (n=91), left colon (n=95), and rectum (n=87). In total, 273 samples were examined. The relative level of mRNA expression of 63 genes potentially involved in various pathways of CRC carcino-genesis was evaluated by reverse transcription polymerase chain reaction. Results: a linear regression model for predicting passport age, including data on gene ex-pression, was characterized by moderate reliability (R2 0.45, DW test 1.54). Age estimation er-rors in the model arise proportionally to its increase, which is associated with the accumulation of epigenetic changes. Maximum accuracy in age prediction is typical for rectal mucosa samples. The first statistically significant division (primary classification
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