Background: Giant cell granulomas of the jaws are reactive bone lesions that impact bone remodeling. The specific pathophysiology was unclear, although osteoclast-type giant and stromal cells were suggested as major modulating factors. Aim of the study: The study aims to determine the levels of two bone regulators, RANK and osteocalcin, in central giant cell granuloma and their correlation with aggressive behavior. Material and method: Twenty-one formalin-fied paraffin-embedded tissue blocks of central giant cell granuloma were collected from laboratory archives and have been made based on clinical and histologic findings. Polyclonal antibodies for RANK and osteocalcin (OC) were used for immunohistochemical (IHC) procedures, and their epression and staining-intensity-distribution (SID) scores were analyzed. Results: Non-aggressive cases showed slightly higher RANK epression, but this was not significant. However, the SID score was significantly higher in non-aggressive cases (P=0.02088). A strong correlation between RANK epression and SID scores was seen in aggressive CGCG (r=0.728, P=0.026). OC epression was significantly higher in aggressive CGCG (30.16%) compared to non-aggressi
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