Background: Subclinical left ventricle dysfunction among patient with chronic hepatitis C is under detected and therefore untreated. The current study aimed to use the Two-Dimensional Speckle tracking echocardiography in the assessment of global and regional function of the left ventricle (LV) myocardium in chronic viral hepatitis C patients with preserved left ventricle ejection fraction (LVEF). Methodology: In this cross-sectional study, 100 participants were divided into 2 groups; 50 patients with chronic hepatitis C and 50 normal healthy matched volunteers as controls. All participants were investigated using conventional echocardiography and 2D speckle tracking. Results: There was no statistically significant difference between hepatitis C group in comparison with control group according to Ejection Fraction (EF%) and fraction shortening (FS) (P= 0.074 and 0.393, respectively). It was be found that 14% of patients suffered from abnormal global longitudinal strain regardless a normal Left ventricular ejection fraction (LVEF). There was significant difference at the level of average GLS (P < 0.001) and as regard regional longitudinal strain, there were significant difference
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