Neutrophil migration in inflammation and infection: role in the formation of neutrophilic phenotypes

Neutrophil migration and its role in shaping neutrophil phenotypes during inflammation have been the focus of increased interest in the past decade. New model systems have facilitated the study of neutrophil behavior in damaged and infected tissues. Neutrophils have long been known to be rapidly recruited from the bloodstream to inflammation sites in response to infection or injury. However, reverse transendothelial migration was first demonstrated only in 2006. To date, research on reverse transendothelial migration and its mechanisms has been dominated by international studies, leaving gaps in understanding. This review synthesizes global findings on reverse transendothelial migration in order to attract the attention of Russia’s scientists to this phenomenon in infectious and inflammatory diseases. Keywords: neutrophils, migration, inflammation, infection, neutrophil heterogeneity, neutrophilic phenotype