Mirabegron: useful side effects and new promising areas of application.

Introduction. Mirabegron is a β3-adrenergic receptor agonist (β3-AR) that is registered and widely used for the treatment of overactive bladder (OAB). Initially, the drug was studied for the treatment of metabolic syndrome, but then showed the ability to influence the symptoms of urgent frequent urination. As a result, it was registered for the indication «OAB». However, the effect of mirabegron on fat metabolism and other metabolic effects should also be taken into account. These side effects of mirabegron can be «beneficial» and provide a dual effect: correction of symptoms of lower urinary tract dysfunction (LUTS) and, for example, metabolic disorders. This review is devoted to the analysis of publications that demonstrate concomitant beneficial effects of mirabegron. Materials and methods. 32 most significant publications from PubMed and eLibrary electronic libraries were analyzed. Results. The analysis of experimental studies showed that β3-AR are a target for new pharmacological approaches in the treatment of metabolic, cardiovascular, urological and ocular diseases. Potential targets of β3-AR agonists were identified as: brain, heart, adipose tissue, retina, kidneys, bladd