Metabolic risk factors and urinary stones formation. VII: Uricosuria lithogenic features in men and women.

Introduction. Hyperuricosuria usually considered as the main metabolic factor in the formation of uric acid stones, but this issue remains unclear. Gender differences in the prevalence of urolithiasis (UL) indicate the need for a more detailed study of the lithogenic properties of uricosuria and its role in the development of various metabolic types of UL. In this study, was investigated the effect of varying degrees of uricosuria in men and women with UL on metabolic parameters and the frequency of detection of urinary stones of different chemical composition. Materials and methods. A total of 982 patientsа with UL (439 men and 543 women aged 18 to 79 years)were examined. To assess the lithogenic activity of uricosuria in men and women with UL, the values of uric acid excretion (in mmol/day) were ranked in ascending order and divided into 10 equal parts (ten 10%-х percentilesей). In each of the ranges, the percentage distribution of types of urinary stones and biochemical parameters of urine and blood were determined. Results. As the degree of uricosuria increased from minimum to maximum values in men and women, there were no differences in the percentage distribution of uric ac