Introduction: Consumption of anticoagulant drugs such as warfarin is the main therapy in patients with heart valve disease. Prophylactic antibiotics are recommended for patients with heart disease prior to tooth extraction.Objective: To describe the comprehensive dental management of a patient with a history of heart disease and chronic anticoagulant therapy undergoing multiple tooth extractions.Case: A 67-year-old female patient came to UMY Dental Hospital complaining of discomfort when chewing food because of remaining roots in several of her upper right posterior teeth. This started with a tooth that had cavities and was not treated, causing the crown of the tooth to break little by little on its own. The tooth had hurt about 2 months prior, and she had taken painkillers (Paracetamol). Currently, there are no complaints of pain or other accompanying symptoms. The patient has a history of heart disease since childhood and is currently taking anticoagulant medication (Notisil®). Objective examination showed root residue in teeth 15 and 16, percussion (-), palpation (-), and bitetest (-).Outcome: The patient was given prophylactic antibiotics 60 minutes before tooth extraction and
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