This comprehensive review explores the intricate relationship between curcumin and autophagy in the context of Cardiovascular Disease (CVD). It provides a detailed overview of autophagy, its important role in maintaining cellular homeostasis, and its dysregulation in different types of cardiovascular disease, including atherosclerosis, coronary artery disease, and diabetic cardiomyopathy. This review investigates the mechanisms through which curcumin modulates autophagy, highlighting its potential as a therapeutic agent. By discussing the impact of curcumin on CVD, we offer valuable insights into its potential benefits in the prevention and treatment of CVD. Overall, this review highlights the significance of curcumin-mediated autophagy modulation as a promising avenue for addressing the global burden of cardiovascular disease. Keywords: Curcumin, Cardiovascular disease, Autophagy, Coronary artery disease, Cardiomyopathy, Atherosclerosis
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