Neurofibromatosis type 1 (NF1) (von Recklinghausen’s disease) is an autosomal dominant disorder characterized by café-au-lait spots, pigmented hamartomas of the iris, and multiple neurofibromas. Patients can present with hemorrhage secondary to trauma or rarely with spontaneous hemorrhage. We report a 42-year-old man with long-term history of a giant neurofibroma on his back who suffered from spontaneous hemorrhage. Series examinations and treatments were given to stop bleeding and eventually to heal the wound.
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