Cytotoxic Lesion of the Corpus Callosum (CLOCCs)

A 19 year old male with no past medical history presented to the emergency department with an altered mental status, seizures and fever. Laboratory examination showed no abnormalities, further examination with urine and serum drug screening however, revealed high levels of benzodiazepines. Initial head computed tomography came back normal, therefore an MRI was performed. It featured focal hypersignal lesion of the splenium of the corpus callosum on both T2 and FLAIR (Figure A and B) weighted images with diffusion restriction (Figure D).