Effect of Selected Diets/Xanthone Derivatives on Morphotic Image of Bone Marrow and Other Tissues

Introduction: The diet as well as some xanthone derivatives can influence the processes occurring in the bone marrow, which is a hematopoietic organ and plays an important role in the immune system. Changes in the proportions of individual cell lines may lead to illnesses such as anemia or blood coagulation disorders. Aim: The aim of the study is to identify the effect of selected xanthone derivatives and high-fat diet on the morphological construction of individual cell lines in the bone marrow (erythrocyte line, myeloblastic line, monocytic line, megakaryocytic line, lymphoid line). Material and Methods: The studies were carried out on 4 groups of CD1 mice (n = 10): control (c), diabetes induced by a high-fat diet (f) and two derivatives of xanthone (gr. 1 and 2). Five-week-old animals received a standard or an enriched in fat diet for another 5 weeks. After decapitation of animals the bone marrow smear was prepared. The stained preparations were observed under a microscope and hematopoietic cells were counted. Results: Based on the results and preliminary statistical treatment, it was found that there is a relationship between the diet used and changes in the proportion of ce